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1

Pumilio1 Haploinsufficiency Leads to SCA1-like Neurodegeneration by Increasing Wild-Type Ataxin1 Levels

Gennarino, Vincenzo A., Singh, Ravi K., White, Joshua J., De Maio, Antonia, Han, Kihoon, Kim, Ji-Yoen, Jafar-Nejad, Paymaan, di Ronza, Alberto, Kang, Hyojin, Sayegh, Layal S., Cooper, Thomas A., Orr,

Journal:

Year:

2015

Language:

english

File:

PDF, 3.47 MB

english, 2015

2

Phosphorylation of ATXN1 at Ser776 in the cerebellum

Nathan D. Jorgensen, J. Michael Andresen, Sara Lagalwar, Ben Armstrong, Sam Stevens, Courtney E. Byam, Lisa A. Duvick, Shaojuan Lai, Paymaan Jafar-Nejad, Huda Y. Zoghbi, H. Brent Clark, Harry T. Orr

Journal:

Journal of Neurochemistry

Year:

2009

Language:

english

File:

PDF, 1011 KB

english, 2009

3

Novel function of the class I bHLH protein Daughterless in the negative regulation of proneural gene expression in the Drosophila eye

Lim, Janghoo, Jafar-Nejad, Hamed, Hsu, Ya-Chieh, Choi, Kwang-Wook

Journal:

Year:

2008

Language:

english

File:

PDF, 977 KB

english, 2008

4

Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1

Lim, Janghoo, Crespo-Barreto, Juan, Jafar-Nejad, Paymaan, Bowman, Aaron B., Richman, Ronald, Hill, David E., Orr, Harry T., Zoghbi, Huda Y.

Journal:

Year:

2008

Language:

english

File:

PDF, 728 KB

english, 2008

5

The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis

Hamaratoglu, Fisun, Willecke, Maria, Kango-Singh, Madhuri, Nolo, Riitta, Hyun, Eric, Tao, Chunyao, Jafar-Nejad, Hamed, Halder, Georg

Journal:

Nature Cell Biology

Year:

2005

Language:

english

File:

PDF, 3.02 MB

english, 2005

6

Duplication of Atxn1l suppresses SCA1 neuropathology by decreasing incorporation of polyglutamine-expanded ataxin-1 into native complexes

Bowman, Aaron B, Lam, Yung C, Jafar-Nejad, Paymaan, Chen, Hung-Kai, Richman, Ronald, Samaco, Rodney C, Fryer, John D, Kahle, Juliette J, Orr, Harry T, Zoghbi, Huda Y

Journal:

Nature Genetics

Year:

2007

Language:

english

File:

PDF, 414 KB

english, 2007

7

Chlorpromazine-induced Erythrocyte Shape Change in Rats with Obstructive Cholestasis

AHMAD REZA DEHPOUR, PAYMAAN JAFAR-NEJAD, ALI REZA MANI, BEHDAD GHARIB, NASER EBRAHIMI DARYANI

Journal:

Journal of Pharmacy and Pharmacology

Year:

1999

Language:

english

File:

PDF, 87 KB

english, 1999

8

Regulation of mammalian Notch signaling and embryonic development by the protein O-glucosyltransferase Rumi

Rodrigo Fernandez-Valdivia, Hideyuki Takeuchi, Amin Samarghandi, Mario Lopez, Jessica Leonardi, Robert Haltiwanger, Hamed Jafar-Nejad

Journal:

Developmental Biology

Year:

2011

Language:

english

File:

PDF, 125 KB

english, 2011

9

The AXH Domain of Ataxin-1 Mediates Neurodegeneration through Its Interaction with Gfi-1/Senseless Proteins

Hiroshi Tsuda, Hamed Jafar-Nejad, Akash J. Patel, Yaling Sun, Hung-Kai Chen, Matthew F. Rose, Koen J.T. Venken, Juan Botas, Harry T. Orr, Hugo J. Bellen, Huda Y. Zoghbi

Journal:

Year:

2005

Language:

english

File:

PDF, 984 KB

english, 2005

10

ATAXIN-1 Interacts with the Repressor Capicua in Its Native Complex to Cause SCA1 Neuropathology

Yung C. Lam, Aaron B. Bowman, Paymaan Jafar-Nejad, Janghoo Lim, Ronald Richman, John D. Fryer, Eric D. Hyun, Lisa A. Duvick, Harry T. Orr, Juan Botas, Huda Y. Zoghbi

Journal:

Year:

2006

Language:

english

File:

PDF, 1.77 MB

english, 2006

11

Rumi Is a CAP10 Domain Glycosyltransferase that Modifies Notch and Is Required for Notch Signaling

Melih Acar, Hamed Jafar-Nejad, Hideyuki Takeuchi, Akhila Rajan, Dafina Ibrani, Nadia A. Rana, Hongling Pan, Robert S. Haltiwanger, Hugo J. Bellen

Journal:

Year:

2008

Language:

english

File:

PDF, 2.09 MB

english, 2008

12

Sec15, a Component of the Exocyst, Promotes Notch Signaling during the Asymmetric Division of Drosophila Sensory Organ Precursors

Hamed Jafar-Nejad, Hillary K. Andrews, Melih Acar, Vafa Bayat, Frederik Wirtz-Peitz, Sunil Q. Mehta, Juergen A. Knoblich, Hugo J. Bellen

Journal:

Developmental Cell

Year:

2005

Language:

english

File:

PDF, 960 KB

english, 2005

13

Numb: “Adapting” Notch for Endocytosis

Hamed Jafar-Nejad, Koenraad K. Norga, Hugo J. Bellen

Journal:

Developmental Cell

Year:

2002

Language:

english

File:

PDF, 82 KB

english, 2002

14

RAS–MAPK–MSK1 pathway modulates ataxin 1 protein levels and toxicity in SCA1

Park, Jeehye, Al-Ramahi, Ismael, Tan, Qiumin, Mollema, Nissa, Diaz-Garcia, Javier R., Gallego-Flores, Tatiana, Lu, Hsiang-Chih, Lagalwar, Sarita, Duvick, Lisa, Kang, Hyojin, Lee, Yoontae, Jafar-Nejad,

Journal:

Year:

2013

Language:

english

File:

PDF, 2.01 MB

english, 2013

15

Rumi functions as both a protein O-glucosyltransferase and a protein O-xylosyltransferase

Takeuchi, H., Fernandez-Valdivia, R. C., Caswell, D. S., Nita-Lazar, A., Rana, N. A., Garner, T. P., Weldeghiorghis, T. K., Macnaughtan, M. A., Jafar-Nejad, H., Haltiwanger, R. S.

Journal:

Proceedings of the National Academy of Sciences

Year:

2011

Language:

english

File:

PDF, 962 KB

english, 2011

16

Rumi functions as both a protein O-glucosyltransferase and a protein O-xylosyltransferase

Hideyuki Takeuchi, Rodrigo C. Fernández-Valdivia, Devin S. Caswell, Aleksandra Nita-Lazar, Nadia A. Rana, Thomas P. Garner, Thomas K. Weldeghiorghis, Megan A. Macnaughtan, Hamed Jafar-Nejad and Robert

Journal:

Proceedings of the National Academy of Sciences

Year:

2011

Language:

english

File:

PDF, 1.51 MB

english, 2011

17

Differential Repression by Freud-1/CC2D1A at a Polymorphic Site in the Dopamine-D2 Receptor Gene

Rogaeva, A., Ou, X.-M., Jafar-Nejad, H., Lemonde, S., Albert, P. R.

Journal:

Journal of Biological Chemistry

Year:

2007

Language:

english

File:

PDF, 843 KB

english, 2007

18

Gfi/Pag-3/Senseless Zinc Finger Proteins: a Unifying Theme?

Jafar-Nejad, H., Bellen, H. J.

Journal:

Molecular and Cellular Biology

Year:

2004

Language:

english

File:

PDF, 697 KB

english, 2004

19

Regulation of mammalian Notch signaling and embryonic development by the protein O-glucosyltransferase Rumi

Fernandez-Valdivia, R., Takeuchi, H., Samarghandi, A., Lopez, M., Leonardi, J., Haltiwanger, R. S., Jafar-Nejad, H.

Journal:

Development (The Company of Biologists)

Year:

2011

Language:

english

File:

PDF, 2.64 MB

english, 2011

20

Mapping Drosophila mutations with molecularly defined P element insertions

Zhai, R. G., Hiesinger, P. R., Koh, T.-W., Verstreken, P., Schulze, K. L., Cao, Y., Jafar-Nejad, H., Norga, K. K., Pan, H., Bayat, V., Greenbaum, M. P., Bellen, H. J.

Journal:

Proceedings of the National Academy of Sciences

Year:

2003

Language:

english

File:

PDF, 695 KB

english, 2003

21

Multiple O-glucosylation sites on Notch function as a buffer against temperature-dependent loss of signaling

Leonardi, J., Fernandez-Valdivia, R., Li, Y.-D., Simcox, A. A., Jafar-Nejad, H.

Journal:

Development (The Company of Biologists)

Year:

2011

Language:

english

File:

PDF, 4.34 MB

english, 2011

22

The insulin-like growth factor pathway is altered in spinocerebellar ataxia type 1 and type 7

Gatchel, J. R., Watase, K., Thaller, C., Carson, J. P., Jafar-Nejad, P., Shaw, C., Zu, T., Orr, H. T., Zoghbi, H. Y.

Journal:

Proceedings of the National Academy of Sciences

Year:

2008

Language:

english

File:

PDF, 977 KB

english, 2008

23

Regional rescue of spinocerebellar ataxia type 1 phenotypes by 14-3-3 ε haploinsufficiency in mice underscores complex pathogenicity in neurodegeneration

Jafar-Nejad, Paymaan, Ward, Christopher S., Richman, Ronald, Orr, Harry T., Zoghbi, Huda Y.

Journal:

Proceedings of the National Academy of Sciences

Year:

2011

Language:

english

File:

PDF, 742 KB

english, 2011

24

Senseless acts as a binary switch during sensory organ precursor selection

Jafar-Nejad, H.

Journal:

Genes & Development

Year:

2003

Language:

english

File:

PDF, 677 KB

english, 2003

25

Role of glycans and glycosyltransferases in the regulation of Notch signaling

Jafar-Nejad, H., Leonardi, J., Fernandez-Valdivia, R.

Journal:

Year:

2010

Language:

english

File:

PDF, 609 KB

english, 2010

26

Senseless and Daughterless confer neuronal identity to epithelial cells in the Drosophila wing margin

Jafar-Nejad, H.

Journal:

Development (The Company of Biologists)

Year:

2006

Language:

english

File:

PDF, 5.94 MB

english, 2006

27

The Protein O-glucosyltransferase Rumi Modifies Eyes Shut to Promote Rhabdomere Separation in Drosophila

Haltom, Amanda R., Lee, Tom V., Harvey, Beth M., Leonardi, Jessica, Chen, Yi-Jiun, Hong, Yang, Haltiwanger, Robert S., Jafar-Nejad, Hamed, Perrimon, Norbert

Journal:

Year:

2014

Language:

english

File:

PDF, 3.35 MB

english, 2014

28

Negative Regulation of Notch Signaling by Xylose

Lee, Tom V., Sethi, Maya K., Leonardi, Jessica, Rana, Nadia A., Buettner, Falk F. R., Haltiwanger, Robert S., Bakker, Hans, Jafar-Nejad, Hamed, Perrimon, Norbert

Journal:

Year:

2013

Language:

english

File:

PDF, 10.42 MB

english, 2013

29

The multiple roles of EGF repeat O -glycans in animal development

Haltom, Amanda R., Jafar-Nejad, Hamed

Journal:

Year:

2015

Language:

english

File:

PDF, 1.75 MB

english, 2015

30

A congenital disorder of deglycosylation: Biochemical characterization of N -glycanase 1 deficiency in patient fibroblasts

He, Ping, Grotzke, Jeff E, Ng, Bobby G, Gunel, Murat, Jafar-Nejad, Hamed, Cresswell, Peter, Enns, Gregory M, Freeze, Hudson H

Journal:

Year:

2015

Language:

english

File:

PDF, 1.06 MB

english, 2015

31

Regional rescue of spinocerebellar ataxia type 1 phenotypes by 14-3-3ε haploinsufficiency in mice underscores complex pathogenicity in neurodegeneration

Paymaan Jafar-Nejad, Christopher S. Ward, Ronald Richman, Harry T. Orr and Huda Y. Zoghbi

Journal:

Proceedings of the National Academy of Sciences

Year:

2011

Language:

english

File:

PDF, 1.56 MB

english, 2011

32

Targeting tau protein stability in alzheimer disease to identify novel therapeutic entry points

Lasagna-Reeves, C., Al Ramahi, I., de Haro, M., Rousseaux, M., Kim, J., Jafar-Nejad, P., Vilanova-Velez, L., Westbrook, T., Botas, J., Zoghbi, H.

Journal:

Journal of the Neurological Sciences

Year:

2015

Language:

english

File:

PDF, 52 KB

english, 2015

33

Drosophila embryonic 'fibroblasts': Extending mutant analysis in vitro

Simcox, Amanda A., Austin, Christina, Jacobsen, Thomas, Jafar-Nejad, Hamed

Journal:

Year:

2008

Language:

english

File:

PDF, 497 KB

english, 2008

34

TRIM28 regulates the stability and toxicity of alpha-synuclein and tau through a common mechanism

Rousseaux, M.W.C., de Haro, M., Lasagna-Reeves, C.A., De Maio, A., Jafar-Nejad, P., Park, J., Al-Ramahi, I., Kayed, R., Botas, H., Zoghbi, H.Y.

Journal:

Journal of the Neurological Sciences

Year:

2015

Language:

english

File:

PDF, 70 KB

english, 2015

35

Gene Clusters, Molecular Evolution and Disease: A Speculation

Elizondo, Leah, Jafar-Nejad, Paymaan, Clewing, J., Boerkoel, Cornelius

Journal:

Current Genomics

Year:

2009

Language:

english

File:

PDF, 194 KB

english, 2009

36

Mapping sites of O-glycosylation and fringe elongation on Drosophila Notch

Harvey, Beth M., Rana, Nadia A., Moss, Hillary, Leonardi, Jessica, Jafar-Nejad, Hamed, Haltiwanger, Robert S.

Journal:

Journal of Biological Chemistry

Year:

2016

Language:

english

File:

PDF, 32.91 MB

english, 2016

37

Jagged1 heterozygosity in mice results in a congenital cholangiopathy which is reversed by concomitant deletion of one copy of Poglut1 ( Rumi )

Thakurdas, Shakeel M., Lopez, Mario F., Kakuda, Shinako, Fernandez-Valdivia, Rodrigo, Zarrin-Khameh, Neda, Haltiwanger, Robert S., Jafar-Nejad, Hamed

Journal:

Year:

2016

Language:

english

File:

PDF, 1.82 MB

english, 2016

38

Reduction of Nuak1 Decreases Tau and Reverses Phenotypes in a Tauopathy Mouse Model

Lasagna-Reeves, Cristian A., de Haro, Maria, Hao, Shuang, Park, Jeehye, Rousseaux, Maxime W.C., Al-Ramahi, Ismael, Jafar-Nejad, Paymaan, Vilanova-Velez, Luis, See, Lauren, De Maio, Antonia, Nitschke,

Journal:

Year:

2016

Language:

english

File:

PDF, 2.98 MB

english, 2016

39

Playback Theatre as a tool to enhance communication in medical education

Salas, Ramiro, Steele, Kenya, Lin, Amy, Loe, Claire, Gauna, Leslie, Jafar-Nejad, Paymaan

Journal:

Medical Education Online

Year:

2013

Language:

english

File:

PDF, 282 KB

english, 2013

40

Therapeutic reduction of ataxin-2 extends lifespan and reduces pathology in TDP-43 mice

Becker, Lindsay A., Huang, Brenda, Bieri, Gregor, Ma, Rosanna, Knowles, David A., Jafar-Nejad, Paymaan, Messing, James, Kim, Hong Joo, Soriano, Armand, Auburger, Georg, Pulst, Stefan M., Taylor, J. Pa

Journal:

Year:

2017

Language:

english

File:

PDF, 7.87 MB

english, 2017

41

A POGLUT1 mutation causes a muscular dystrophy with reduced notch signaling and satellite cell loss

Servian-Morilla, E., Mavillard, F., Cantero-Nieto, G., Takeuchi, H., Clarimon, J., Bigot, A., Fernández-Chacón, R., Haltiwanger, R., Jafar-Nejad, H., Paradas, C.

Journal:

Neuromuscular Disorders

Year:

2016

Language:

english

File:

PDF, 197 KB

english, 2016

42

Generation of an induced pluripotent stem cell line (CSCRMi001-A) from a patient with a new type of limb-girdle muscular dystrophy (LGMD) due to a missense mutation in POGLUT1 ( Rumi )

Wu, Jianbo, Hunt, Samuel D., Matthias, Nadine, Servián-Morilla, Emilia, Lo, Jonathan, Jafar-Nejad, Hamed, Paradas, Carmen, Darabi, Radbod

Journal:

Stem Cell Research

Year:

2017

Language:

english

File:

PDF, 592 KB

english, 2017

43

Cell Aggregation Assays to Evaluate the Binding of the Drosophila Notch with Trans-Ligands and its Inhibition by Cis-Ligands

Pandey, Ashutosh, Jafar-Nejad, Hamed

Journal:

Journal of Visualized Experiments

Year:

2018

Language:

english

File:

PDF, 1.64 MB

english, 2018

44

A New Model of Alagille Syndrome with Broad Phenotypic Representation

Adams, Joshua M., Jafar-Nejad, Hamed

Journal:

Gastroenterology

Year:

2018

Language:

english

File:

PDF, 303 KB

english, 2018

45

Xylosylation of the Notch receptor preserves the balance between its activation by trans-Delta and inhibition by cis-ligands in Drosophila

Lee, Tom V., Pandey, Ashutosh, Jafar-Nejad, Hamed, Perrimon, Norbert

Journal:

Year:

2017

Language:

english

File:

PDF, 6.22 MB

english, 2017

46

TRIM28 regulates the nuclear accumulation and toxicity of both alpha-synuclein and tau

Rousseaux, Maxime WC, de Haro, Maria, Lasagna-Reeves, Cristian A, De Maio, Antonia, Park, Jeehye, Jafar-Nejad, Paymaan, Al-Ramahi, Ismael, Sharma, Ajay, See, Lauren, Lu, Nan, Vilanova-Velez, Luis, Kli

Journal:

Year:

2016

Language:

english

File:

PDF, 7.63 MB

english, 2016

47

Fringe proteins modulate Notch-ligand cis and trans interactions to specify signaling states

LeBon, Lauren, Lee, Tom V, Sprinzak, David, Jafar-Nejad, Hamed, Elowitz, Michael B

Journal:

Year:

2014

Language:

english

File:

PDF, 5.72 MB

english, 2014

48

Sensitized genetic backgrounds reveal differential roles for EGF repeat xylosyltransferases in Drosophila Notch signaling

Pandey, Ashutosh, Li-Kroeger, David, Sethi, Maya K, Lee, Tom V, Buettner, Falk F R, Bakker, Hans, Jafar-Nejad, Hamed

Journal:

Year:

2018

Language:

english

File:

PDF, 15.62 MB

english, 2018

49

Swaiman's Pediatric Neurology || The Cerebellum and the Hereditary Ataxias

Jafar-Nejad, Paymaan

Year:

2017

Language:

english

File:

PDF, 1.03 MB

english, 2017

50

TARGETING THE ALZHEIMER’S DISEASE-ASSOCIATED RISK GENE, TREM2, WITH ANTISENSE OLIGONUCLEOTIDES

Schoch, Kathleen M., Jafar-nejad, Paymaan, Rigo, Frank, Miller, Timothy M.

Journal:

Alzheimer's & Dementia

Year:

2018

Language:

english

File:

PDF, 219 KB

english, 2018

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